Published study reports neuroprotective molecule could improve memory and cognition, reduce Alzheimer’s degradation
WEST LAFAYETTE, Ind. – A Purdue University graduate and a Purdue Research Park of Northwest Indiana (NWI) startup have published a research study in Bioorganic & Medicinal Chemistry Letters that identifies a small molecule SERCA activator that may improve memory and cognition.
In the Alzheimer’s disease models, the SERCA activator shows promise in reducing the cellular stress and preventing cell loss in neurons. The molecule corrects cells’ calcium ion balance and represents a new therapeutic strategy for neurodegeneration drug development.
“We have identified a compound that could therapeutically slow or halt Alzheimer’s disease, while also demonstrating its ability to cross the blood brain barrier, provide good bioavailability and cause no identifiable off target effects,” said Katie Krajnak, co-author and graduate of Purdue University Northwest’s Department of Biological Sciences.
Krajnak and Russell Dahl, chief executive officer of Neurodon, LLC, co-published the study “A New Target for Alzheimer’s disease: A Small Molecule SERCA Activator is Neuroprotective in vitro and Improves Memory and Cognition in APP/PS1 Mice” in Bioorganic & Medicinal Chemistry Letters. Read the study here.