Scientific Journal

Publications

Our patented compounds are proudly featured in numerous academic publications

Diabetes and related metabolic conditions

Lee, Y., et al. Roles of sarcoplasmic reticulum Ca2+-ATPase pump in the impairments of lymphatic contractile activity in a metabolic syndrome rat model. Sci. Rep. 2020, 105, 12320.

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Singh, R., et al. A role for calcium in resistin transcriptional activation in diabetic hearts. Sci. Rep. 2018, 8, 15633.

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Yuan, L. et al. Etoposide-induced protein 2.4 functions as a regulator of the calcium ATPase and protects pancreatic β-cell survival. J Biol Chem. 2018, 293, 10128–10140.

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Kang, S., et al. Small Molecular Allosteric Activator of the Sarco/Endoplasmic Reticulum Ca2+-ATPase (SERCA) Attenuates Diabetes and Metabolic Disorders. J. Biol. Chem. 2016, 291, 5185-5198.

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Tong, X. et al. SERCA2 Deficiency Impairs Pancreatic β-Cell Function in Response to Diet-Induced Obesity. Diabetes. 2016, 65, 3039–3052.

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Muscular dystrophy and related muscular diseases

Nogami, K. et al. Pharmacological activation of SERCA ameliorates dystrophic phenotypes in dystrophin-deficient mdx mice. Hum. Mol. Genet. 2021, 30, 1006-1019.

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Lindsay, A. et al. Mechanical Factors Tune the Sensitivity of Mdx Muscle to Eccentric Strength Loss and Its Protection by Antioxidant and Calcium Modulators. Skelet. Muscle 2020, 10, 3.

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Qaisar, R., et al. Restoration of SERCA ATPase prevents oxidative stress-related muscle atrophy and weakness. Redox Biol. 2019, 20, 68-74.

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Van Remmen, H. et al. SERCA activation as an intervention to reduce muscle atrophy and weakness. Innov Aging. 2018, 2, 347.

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Qaisar, R. et al. Restoration of Sarcoplasmic Reticulum Ca 2+ ATPase (SERCA) Activity Prevents Age-Related Muscle Atrophy and Weakness in Mice. Int J Mol Sci, 2020, 22, 37.

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Neurodegeneration

Solana-Manrique, C., et al. Oxidative modification impairs SERCA activity in Drosophila and human cell models of Parkinson’s disease. Biochim Biophys Acta Mol Basis Dis, 2021, 1867, 166152.

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Dahl, R. A new target for Parkinson’s disease: Small molecule SERCA activator CDN1163 ameliorates dyskinesia in 6-OHDA-lesioned rats. Bioorg. Med. Chem. 2017, 25, 53-57.

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Krajnak, K. & Dahl, R. A new target for Alzheimer’s disease: A small molecule SERCA activator is neuroprotective in vitro and improves memory and cognition in APP/PS1 mice. Bioorg. Med. Chem. Lett. 2018, 28, 1591-1594.

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Krajnak, K. & Dahl, R. Small molecule SUMOylation activators are novel neuroprotective agents. Bioorg. Med. Chem. Lett. 2018, 28, 405-409.

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Hearing Loss

Li, J. et al. Deletion of Tmtc4 activates the unfolded protein response and causes postnatal hearing loss. J Clin Invest. 2018, 128, 5150–5162.

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Viral Infection

Peng, J. et al. Sarco/Endoplasmic Reticulum Ca 2+ Transporting ATPase (SERCA) Modulates Autophagic, Inflammatory, and Mitochondrial Responses during Influenza A Virus Infection in Human Lung Cells. J Virol, 2021, 95, e00217-21.

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