Scientific Journal

Diabetes and related
metabolic conditions

Lee, Y. et al. Roles of sarcoplasmic reticulum Ca2+-ATPase pump in the impairments of lymphatic contractile activity in a metabolic syndrome rat model. Sci. Rep. 2020, 105, 12320.

Singh, R. et al. A role for calcium in resistin transcriptional activation in diabetic hearts. Sci. Rep. 2018, 8, 15633.

Yuan, L. et al. Etoposide-induced protein 2.4 functions as a regulator of the calcium ATPase and protects pancreatic β-cell survival. J. Biol. Chem. 2018, 293, 10128–10140.

Kang, S. et al. Small Molecular Allosteric Activator of the Sarco/Endoplasmic Reticulum Ca2+-ATPase (SERCA) Attenuates Diabetes and Metabolic Disorders. J. Biol. Chem. 2016, 291, 5185-5198.

Kimura, T. et al. Sarco/Endoplasmic Reticulum Ca2+-ATPase 2 Activator Ameliorates Endothelial Dysfunction; Insulin Resistance in Diabetic Mice. Cells. 2022, 11, 1488.

Tong, X. et al. SERCA2 Deficiency Impairs Pancreatic β-Cell Function in Response to Diet-Induced Obesity. Diabetes. 2016, 65, 3039–3052.

Nguyen, H.T. et al. CDN1163, an activator of sarco/endoplasmic reticulum Ca2+ ATPase, up-regulates mitochondrial functions and protects against lipotoxicity in pancreatic β-cells. Br. J. Pharmacol. 2023.

Muscular dystrophy and
related muscular diseases

Nogami, K. et al. Pharmacological activation of SERCA ameliorates dystrophic phenotypes in dystrophin-deficient mdx mice. Hum. Mol. Genet. 2021, 30, 1006-1019.

Lindsay, A. et al. Mechanical Factors Tune the Sensitivity of Mdx Muscle to Eccentric Strength Loss and Its Protection by Antioxidant and Calcium Modulators. Skelet. Muscle 2020, 10, 3.

Qaisar, R. et al. Restoration of SERCA ATPase prevents oxidative stress-related muscle atrophy and weakness. Redox Biol. 2019, 20, 68-74.

Van Remmen, H. et al. SERCA activation as an intervention to reduce muscle atrophy and weakness. Innov. Aging. 2018, 2, 347.

Mengeste, A.M. et al. The small molecule SERCA activator CDN1163 increases energy metabolism in human skeletal muscle cells. Curr. Res. Pharmacol Drug Discov. 2021, 2, 100060.

Qaisar, R. et al. Restoration of Sarcoplasmic Reticulum Ca2+-ATPase (SERCA) Activity Prevents Age-Related Muscle Atrophy and Weakness in Mice. Int J. Mol. Sci, 2020, 22, 37.


Solana-Manrique, C. et al. Oxidative modification impairs SERCA activity in Drosophila and human cell models of Parkinson’s disease. Biochim Biophys Acta Mol. Basis Dis., 2021, 1867, 166152.

Zhang, W. et al. Restoration of Sarco/Endoplasmic Reticulum Ca2+-ATPase Activity Functions as a Pivotal Therapeutic Target of Anti-Glutamate-Induced Excitotoxicity to Attenuate Endoplasmic Reticulum Ca2+ Depletion. Front Pharmacol. 2022, 13, 877175.

Dahl, R. A new target for Parkinson’s disease: Small molecule SERCA activator CDN1163 ameliorates dyskinesia in 6-OHDA-lesioned rats. Bioorg. Med. Chem. 2017, 25, 53-57.

Krajnak, K. & Dahl, R. A new target for Alzheimer’s disease: A small molecule SERCA activator is neuroprotective in vitro and improves memory and cognition in APP/PS1 mice. Bioorg. Med. Chem. Lett. 2018, 28, 1591-1594.

Krajnak, K. & Dahl, R. Small molecule SUMOylation activators are novel neuroprotective agents. Bioorg. Med. Chem. Lett. 2018, 28, 405-409.

Qaisar, R. et al. Restoration of Sarcoplasmic Reticulum Ca2+-ATPase (SERCA) Activity Prevents Age-Related Muscle Atrophy and Weakness in Mice. Int. J. Mol. Sci, 2020, 22, 37.

Dahl, R. et al. Positive Allosteric Modulator of SERCA Pump NDC-1173 Exerts Beneficial Effects in Mouse Model of Alzheimer’s Disease. Int. J. Mol. Sci. 2023, 24, 11057. 

Protection from
environmental toxins

Kong, A. et al. Cadmium induces triglyceride levels via microsomal triglyceride transfer protein (MTTP) accumulation caused by lysosomal deacidification regulated by endoplasmic reticulum (ER) Ca2+ homeostasis. Chem. Biol. Interact. 2021, 348, 109649.

Li, S. et al. Neonicotinoid insecticides triggers mitochondrial bioenergetic dysfunction via manipulating ROS-calcium influx pathway in the liver. Ecotoxicol. Environ. Saf. 2021, 224, 112690.

Li, K. et al. Cadmium Disrupted ER Ca2+Homeostasis by Inhibiting SERCA2 Expression and Activity to Induce Apoptosis in Renal Proximal Tubular Cells. Int. J. Mol. Sci. 2023, 24, 5979. 

Hearing loss

Li, J. et al. Deletion of Tmtc4 activates the unfolded protein response and causes postnatal hearing loss. J. Clin. Invest. 2018, 128, 5150–5162.

Viral infection

Peng, J. et al. Sarco/Endoplasmic Reticulum Ca2+ Transporting ATPase (SERCA) Modulates Autophagic, Inflammatory, and Mitochondrial Responses during Influenza A Virus Infection in Human Lung Cells. J. Virol, 2021, 95, e00217-21.

Neuropathic pain

Li, S. et al. Sarco/endoplasmic reticulum Ca2+-ATPase 2b mediates oxidation-induced endoplasmic reticulum stress to regulate neuropathic pain. Br. J. Pharmacol. 2021, published online Nov. 22, 2021.

Immune response

Hunter, K.D. et al. Acute activation of SERCA with CDN1163 attenuates IgE-mediated mast cell activation through selective impairment of ROS and p38 signaling. FASEB J. 2023, 37, e22748.

Cardiovascular disease

Xiong, X. et al. Sarco/endoplasmic reticulum Ca2+ ATPase (SERCA)-mediated ER stress crosstalk with autophagy is involved in tris(2-chloroethyl) phosphate stress-induced cardiac fibrosis. J. Inorg. Biochem. 2022 Nov;236:111972.