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Bednarski, T.K. et al. Pharmacological SERCA activation limits diet-induced steatohepatitis and restores liver metabolic function in mice. J. Lipid Res. 2024, 65, 100558.
Nguyen, H.T. et al. CDN1163, an activator of sarco/endoplasmic reticulum Ca2+ ATPase, up-regulates mitochondrial functions and protects against lipotoxicity in pancreatic β-cells. Br. J. Pharmacol. 2023, 180, 2762.
Kimura, T. et al. Sarco/Endoplasmic Reticulum Ca2+-ATPase 2 Activator Ameliorates Endothelial Dysfunction; Insulin Resistance in Diabetic Mice. Cells. 2022, 11, 1488.
Li, S. et al. Sarco/endoplasmic reticulum Ca2+ -ATPase (SERCA2b) mediates oxidation-induced endoplasmic reticulum stress to regulate neuropathic pain. Br. J. Pharmacol. 2022, 179, 2016.
Mengeste. A.M. et al. The small molecule SERCA activator CDN1163 increases energy metabolism in human skeletal muscle cells. Curr. Res. Pharmacol. Drug Discov. 2021, 2, 100060.
Lee, Y. et al. Roles of sarcoplasmic reticulum Ca2+-ATPase pump in the impairments of lymphatic contractile activity in a metabolic syndrome rat model. Sci. Rep. 2020, 105, 12320.
Yuan, L. et al. Etoposide-induced protein 2.4 functions as a regulator of the calcium ATPase and protects pancreatic β-cell survival. J. Biol. Chem. 2018, 293, 10128–10140.
Singh, R. et al. A role for calcium in resistin transcriptional activation in diabetic hearts. Sci. Rep. 2018, 8, 15633.
Kang, S. et al. Small Molecular Allosteric Activator of the Sarco/Endoplasmic Reticulum Ca2+-ATPase (SERCA) Attenuates Diabetes and Metabolic Disorders. J. Biol. Chem. 2016, 291, 5185-5198.
Tong, X. et al. SERCA2 Deficiency Impairs Pancreatic β-Cell Function in Response to Diet-Induced Obesity. Diabetes. 2016, 65, 3039–3052.
Zhang, Y. et al. THADA inhibition in mice protects against type 2 diabetes mellitus by improving pancreatic β-cell function and preserving β-cell mass. Nat Commun. 2023, 14, 1020.
Liiv, M. et al. ER calcium depletion as a key driver for impaired ER-to-mitochondria calcium transfer and mitochondrial dysfunction in Wolfram syndrome. Nat Commun. 2024, 15, 6143.
Yuan, L. et al. Etoposide-induced protein 2.4 functions as a regulator of the calcium ATPase and protects pancreatic β-cell survival. J Biol Chem. 2018, 293, 10128–10140.
Sharlo, K.A. et al. The Effect of SERCA Activation on Functional Characteristics and Signaling of Rat Soleus Muscle upon 7 Days of Unloading. Biomolecules. 2023, 13, 1354.
Nogami, K. et al. Pharmacological activation of SERCA ameliorates dystrophic phenotypes in dystrophin-deficient mdx mice. Hum. Mol. Genet. 2021, 30, 1006-1019.
Mengeste, A.M. et al. The small molecule SERCA activator CDN1163 increases energy metabolism in human skeletal muscle cells. Curr. Res. Pharmacol Drug Discov. 2021, 2, 100060.
Lindsay, A. et al. Mechanical Factors Tune the Sensitivity of Mdx Muscle to Eccentric Strength Loss and Its Protection by Antioxidant and Calcium Modulators. Skelet. Muscle 2020, 10, 3.
Qaisar, R. et al. Restoration of Sarcoplasmic Reticulum Ca2+-ATPase (SERCA) Activity Prevents Age-Related Muscle Atrophy and Weakness in Mice. Int J. Mol. Sci, 2020, 22, 37.
Qaisar, R. et al. Restoration of SERCA ATPase prevents oxidative stress-related muscle atrophy and weakness. Redox Biol. 2019, 20, 68-74.
Van Remmen, H. et al. SERCA activation as an intervention to reduce muscle atrophy and weakness. Innov. Aging. 2018, 2, 347.
Dahl, R. & Bezprozvanny, I. SERCA pump as a novel therapeutic target for treating neurodegenerative disorders. Biochem. Biophys. Res. Commun. 2024, 734, 150748.
Li, H. et al. Heat stress induces calcium dyshomeostasis to subsequent cognitive impairment through ERS-mediated apoptosis via SERCA/PERK/eIF2α pathway. Cell Death Discov. 2024, 10, 280.
Wang, Y. et al. Involvement of nucleus accumbens SERCA2b in methamphetamine-induced conditioned place preference. Addict. Biol. 2024, 29, e13382.
Dahl, R. et al. Positive Allosteric Modulator of SERCA Pump NDC-1173 Exerts Beneficial Effects in Mouse Model of Alzheimer’s Disease. Int. J. Mol. Sci. 2023, 24, 11057.
Rakovskaya, A. et al. Positive Allosteric Modulators of SERCA Pump Restore Dendritic Spines and Rescue Long-Term Potentiation Defects in Alzheimer’s Disease Mouse Model. Int. J. Mol. Sci. 2023, 24, 13973.
Klocke, B. et al. Chronic pharmacological activation of SERCA with CDN1163 affects spatial cognitive flexibility but not attention and impulsivity in mice. Behav. Pharmacol. 2023, 34, 477.
Zhang, W. et al. Restoration of Sarco/Endoplasmic Reticulum Ca2+-ATPase Activity Functions as a Pivotal Therapeutic Target of Anti-Glutamate-Induced Excitotoxicity to Attenuate Endoplasmic Reticulum Ca2+ Depletion. Front Pharmacol. 2022, 13, 877175.
Solana-Manrique, C. et al. Oxidative modification impairs SERCA activity in Drosophila and human cell models of Parkinson’s disease. Biochim. Biophys. Acta Mol. Basis Dis., 2021, 1867, 166152.
Britzolaki, A. et al. Chronic but not acute pharmacological activation of SERCA induces behavioral and neurochemical effects in male and female mice. Behav. Brain Res. 2021, 399, 112984.
Krajnak, K. & Dahl, R. A new target for Alzheimer’s disease: A small molecule SERCA activator is neuroprotective in vitro and improves memory and cognition in APP/PS1 mice. Bioorg. Med. Chem. Lett. 2018, 28, 1591-1594.
Krajnak, K. & Dahl, R. Small molecule SUMOylation activators are novel neuroprotective agents. Bioorg. Med. Chem. Lett. 2018, 28, 405-409.
Dahl, R. A new target for Parkinson’s disease: Small molecule SERCA activator CDN1163 ameliorates dyskinesia in 6-OHDA-lesioned rats. Bioorg. Med. Chem. 2017, 25, 53-57.
Wang, Y. et al. SERCA2 dysfunction triggers hypertension by interrupting mitochondrial homeostasis and provoking oxidative stress. Free Radic. Biol. Med. 2024, 212, 284.
Mainali, N. et al. Myocardial infarction elevates endoplasmic reticulum stress and protein aggregation in heart as well as brain. Mol. Cell. Biochem. 2024, 479, 2741.
Šeflová, et al. Mechanisms for cardiac calcium pump activation by its substrate and a synthetic allosteric modulator using fluorescence lifetime imaging. PNAS Nexus. 2023, 3, pgad453.
Yu, W. et al. CDN1163 alleviates SERCA2 dysfunction-induced pulmonary vascular remodeling by inhibiting the phenotypic transition of pulmonary artery smooth muscle cells. Clin Exp Hypertens. 2023, 45, 2272062.
Xiong, X. et al. Sarco/endoplasmic reticulum Ca2+ ATPase (SERCA)-mediated ER stress crosstalk with autophagy is involved in tris(2-chloroethyl) phosphate stress-induced cardiac fibrosis. J. Inorg. Biochem. 2022, 236, 111972.
Banerjee, D. et al. Pharmacological SERCA Activation Shifts Cardiac Fuel Preference Without Impairing Function in Obese Mice. Circulation. 2023, 148.
Wang, L. et al. SERCA2 dysfunction accelerates angiotensin II-induced aortic aneurysm and atherosclerosis by induction of oxidative stress in aortic smooth muscle cells. J Mol Cell Cardiol. 2025, 200, 68-81.
Hunter, K.D. et al. Acute activation of SERCA with CDN1163 attenuates IgE-mediated mast cell activation through selective impairment of ROS and p38 signaling. FASEB J. 2023, 37, e22748.
Peng, J. et al. Sarco/Endoplasmic Reticulum Ca2+ Transporting ATPase (SERCA) Modulates Autophagic, Inflammatory, and Mitochondrial Responses during Influenza A Virus Infection in Human Lung Cells. J. Virol. 2021, 95, e00217.
Li, J. et al. Deletion of Tmtc4 activates the unfolded protein response and causes postnatal hearing loss. J. Clin. Invest. 2018, 128, 5150–5162.
Shiga, Y. et al. Endoplasmic reticulum stress-related deficits in calcium clearance promote neuronal dysfunction that is prevented by SERCA2 gene augmentation. Cell Rep Med. 2024, 29, 101839.
Celli, A. & Mauro, T. LB1714 Increased epidermal penetration in aged skin modulates systemic inflammation. J Invest Dermatol. 2024, 143, S169.
Celli, A. et al. Restoring Endoplasmic Reticulum Calcium Stores in Aged Epidermis Improves the Epidermal Calcium Gradient and Enhances FLG Expression. J Invest Dermatol. 2024, 144, 1169-1172.
Li, K. et al. Cadmium Disrupted ER Ca2+Homeostasis by Inhibiting SERCA2 Expression and Activity to Induce Apoptosis in Renal Proximal Tubular Cells. Int. J. Mol. Sci. 2023, 24, 5979.
Li, S. et al. Neonicotinoid insecticides triggers mitochondrial bioenergetic dysfunction via manipulating ROS-calcium influx pathway in the liver. Ecotoxicol. Environ. Saf. 2021, 224, 112690.
Kong, A. et al. Cadmium induces triglyceride levels via microsomal triglyceride transfer protein (MTTP) accumulation caused by lysosomal deacidification regulated by endoplasmic reticulum (ER) Ca2+ homeostasis. Chem. Biol. Interact. 2021, 348, 109649.
Wang, W. et al. Coexposure to fluoride and sulfur dioxide aggravates enamel mineralization disorders in mice by disrupting calcium homeostasis-mediated endoplasmic reticulum stress. Food Chem Toxicol. 2025, 198, 115317.