In addition to controlling blood glucose, the expert said data indicates Neurodon’s investigational diabetes drug restored beta cell health in several models of the disease, something no other drug on the market can do.
Neurodon’s diabetes drug NDC-0009 has the potential to treat both Type 1 and Type 2 diabetes, as well as pre-diabetes, said John Amatruda, M.D., former senior vice president for diabetes and obesity drug development at Merck. “The drug would be a gamechanger for patients,” Dr Armatruda said.
Orally-available NDC-0009 is one of several first-in-class curative molecules Neurodon is developing for multiple diseases by targeting specific cellular stress pathways.
“We’re gratified for the validation of our hypothesis from such a respected expert with a broad and deep understanding of diabetes drug development,” said Neurodon CEO Russell Dahl, Ph.D. “We hope to continue our rapid-fire progress with positive results, enabling us to begin clinical trials in late 2022,” Dahl said. The company plans to file an investigational new drug (IND) application with the FDA in mid-2022.
“I’ve been very excited to see new research that shows it’s possible to boost calcium handling since a disruption of calcium levels is such a widespread disease mechanism,” said Seth Robia, Ph.D., a researcher at Loyola School of Medicine and member of Neurodon’s SAB. “It makes me very hopeful for our efforts to develop a therapeutic strategy based on restoring healthy calcium handling,” Robia said.